Respiratory involvement in neuromuscular disease

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Respiratory involvement in neuromuscular disease.

72 © Royal College of Physicians 2014. All rights reserved. In neuromuscular disease (NMD), respiratory muscle weakness (RMW) is common and death often results from respiratory failure. RMW initially causes sleep-related hypoventilation, with sleep disruption. With progression, daytime respiratory failure ensues. Bulbar muscle weakness causes diffi culty with speech and swallowing, often compli...

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Neuromuscular disease causing acute respiratory failure.

In the developed world, Guillain-Barré syndrome and myasthenia gravis account for the majority of cases of acute respiratory failure associated with neuromuscular disease. The 4 components that contribute to respiratory failure are upper-airway dysfunction, inspiratory-muscle weakness, expiratory-muscle weakness, and the pulmonary complications associated with these conditions. Careful observat...

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Neuromuscular disease, respiratory failure and cor pulmonale.

Respiratory muscle weakness is an uncommon cause of chronic respiratory failure and a rare cause of cor pulmonale. The problem may not be apparent unless specific physical signs are sought or appropriate investigations performed. We present three patients who presented diagnostic difficulty for prolonged periods until the presence of respiratory muscle weakness was considered. Once the diagnosi...

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ژورنال

عنوان ژورنال: Clinical Medicine

سال: 2014

ISSN: 1470-2118,1473-4893

DOI: 10.7861/clinmedicine.14-1-72